Cox proportional risks models were used to help you estimate RRs and 95% CIs

Cox proportional risks models were used to help you estimate RRs and 95% CIs

RRs (95% CI) of full, ischemic, and hemorrhagic shots by quintiles off shared eating plan score to have magnesium, potassium, and you can calcium supplements intakes when you look at the 86,149 feamales in the newest NHS We and you may 94,715 ladies in brand new NHS II step 1

We current the fresh meta-analyses regarding potential knowledge regarding diet magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) intakes and you can risk of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) off complete, ischemic, and you may hemorrhagic strokes by the quintiles away from shared diet plan scores to own magnesium, potassium, and you can calcium supplements consumption inside the 86,149 feamales in the NHS I and 94,715 ladies in this new NHS II 1

We up-to-date the meta-analyses of potential knowledge out of weightloss magnesium ( 21), potassium ( 22), and you may calcium ( 23) intakes and you can likelihood of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I checked-out overall and you may fat reduction intakes of each and every mineral and exposure of coronary attack to determine any potential nonlinear connection that with limited cubic splines; yet not, no significant deviation away from linearity are observed. At exactly the same time, we looked the possibility impact amendment from the ages, blood circulation pressure, or diabetic issues towards the relatives anywhere between total consumption of all of the step three minerals and you can risk of overall heart attack. No extreme effect modification was seen by these things.

Previous meta-analyses provided is a result of early in the day analyses throughout the NHS ( 10); these show was replaced of the contributes to the present day investigation. Additionally, brand new literary works try featured, and previous prospective degree ( 8, 24) was in fact found in these types of updated meta-analyses. Zero anywhere between-degree heterogeneity are observed for your of the step three minerals. The latest mutual RR from complete heart attack are 0.87 (95% CI: 0.83, 0.92) for a hundred-mg/d boost of magnesium consumption, 0.91 (95% CI: 0.88, 0.94) getting a great one thousand-mg/d raise of potassium consumption, and 0.98 (95% CI: 0.94, step 1.02) for a 300-mg/d improve regarding calcium consumption.

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